Publications old







49. Vreeland RFLaude ND, Lambert SM, Heien ML. Microwave-Plasma Dry-Etch for Fabrication of Conducting Polymer Microelectrodes. Analytical Chemistry 2014,  86 (3) 1385–1390.  doi: 10.1021/ac403363a


48. Atcherley CWLaude ND, Parent KL, Heien ML. Fast-Scan Controlled-Adsorption Voltammetry for the Quantification of Absolute Concentrations and Adsorption DynamicsLangmuir 2013, 29 (48), 14885–14892.  doi: 10.1021/la402686s

47. Atcherley CWVreeland RF, Monroe EB, Sanchez-Gomez E, Heien ML. Rethinking Data Collection and Signal Processing. 2. Preserving the Temporal Fidelity of Electrochemical Measurements. Analytical Chemistry. Article ASAP  doi: 10.1021/ac402037k

46. Monroe EB Heien ML. Electrochemical Generation of Hydroxyl Radicals for Examining Protein Structure. Analytical Chemistry 2013 85 (13), 6185-6189. doi: 10.1021/ac400107c

45. Berglund EC, Makos MA, Keighron JD, Phan N, Heien ML, and Ewing AGOral Administration of Methylphenidate Blocks the Effect of Cocaine on Uptake at the Drosophila Dopamine Transporter. ACS Chemical Neuroscience 2013 4 (4), 566-574 doi: 10.1021/cn3002009


44. Laude ND, Atcherley CW, Heien ML.  Rethinking data collection and signal processing.  1. Real-time oversampling filter for chemical measurements. Analytical Chemistry 2012 84 (19), 8422-8426. doi: 10.1021/ac302169y

43. Larsen ST, Heien ML, Taboryski R. Amperometric noise at thin film band electrodes. Analytical Chemistry 2012 84 (18), 7744-7749. doi: 10.1021/ac301136x

42. Larsen ST, Vreeland RF, Heien ML, Taboryski R. Characterization of poly(3,4-ethylenedioxythiophene):tosylate conductive polymer microelectrodes for transmitter detection.  Analyst. 2012 137, 1831-1836.  doi: 10.1039/C2AN16288A


41. Zhang B, Heien ML, Santillo MF, Mellander L, Ewing AG. Temporal resolution in electrochemical imaging on single PC12 cells using amperometry and voltammetry at microelectrode arrays. Analytical Chemistry. 2011 15, 571-7.

40. Santillo MF, Ewing AG, Heien ML. Trends in computational modeling and numerical simulations of electrochemical processes under hydrodynamic flow in microchannels. Analytical and Bioanalytical Chemistry. 2011 399, 189-190. doi: 10.1007/s00216-010-4070-4. PMID20734034.


39. Dominak LM, Omiatek DM, Gundermann EL, Heien ML, Keating CD. Polymeric crowding agents improve passive biomacromolecule encapsulation in lipid vesicles. Langmuir. 2010 26, 13195-131200. doi: 10.1021/la101903r. PMC2919175.

38. Omiatek DM, Cans AS, Heien ML, Ewing AG. Analytical approaches to investigate transmitter content and release from single secretory vesicles. Analytical and Bioanalytical Chemistry. 2010 397, 3269-3279. doi: 10.1007/s00216-010-3698-4. PMID20480152.

37. Heien ML, Piehowski PD, Winograd N, Ewing AG. Lipid detection, identification, and imaging single cells with SIMS. Mass Spectrometric Imaging: History, fundamentals, and protocols, Humana Press Methods in Molecular Biology series. 2010 656, 85-97. doi: 10.1007/978-1-60761-746-4_4. PMID20680585.

36. Makos MA, Omiatek DM, Ewing AG, Heien ML. Development and Characterization of a Voltammetric Carbon-Fiber Microelectrode pH Sensor. Langmuir, 2010 26, 10386 – 10391. doi: 10.1021/la100134r. PMID20380393.

35. Kurczy ME, Piehowski PD, Willingham D,Molyneaux KA, Heien ML, Winograd N, Ewing AG. Nanotome cluster bombardment to recover spatial chemistry after preparation of biological samples for SIMS imaging. Journal of The American Society for Mass Spectrometry. 2010 21, 833-836. doi: 10.1016/j.jasms.2010.01.014. PMC2856613.

34. Dong Y, Heien ML, Kurczy ME, Ewing AG. Probing exocytosis at single cells using electrochemistry. In Chemical Cytometry: Ultrasensive analysis of single cells, Lu C, Ed. Wiley-VCH. 2010, 159-174. doi: 10.1002/9783527629640.ch10.

33. Omiatek DM, Dong Y, Heien ML, Ewing AG. Only a Fraction of Quantal Content is Released During Exocytosis as Revealed by Electrochemical Cytometry of Vesicles. ACS Chemical Neuroscience. 2010 1, 234–245. doi: 10.1021/cn900040e. PMC2847285.

32. Kurczy ME, Piehowski PD, Van Bell CT, Heien ML, Winograd N, Ewing AG. Mass spectrometry imaging of mating Tetrahymena show that changes in cell morphology regulate lipid domain formation. Proceedings of the National Academy of Sciences USA. 2010 107, 2751–2756. doi: 10.1073/pnas.0908101107. PMC2840282.

31. Adams KL, Engelbrektsson J, Voinova M, Zhang B, Eves DJ, Karlsson R, Heien ML, Cans AS, Ewing AG. Steady-state electrochemical determination of lipidic nanotube diameter utilizing an artificial cell model. Analytical Chemistry. 2010 82, 1020-1026. doi: 10.1021/ac902282d. PMC2814003.

30. Makos MA, Kim YC, Han KA, Heien ML, Ewing AG. Using in vivo electrochemistry to study the physiological effects of cocaine and other stimulants on the Drosophila melanogaster dopamine transporter. ACS Chemical Neuroscience. 2010 1, 74–83. doi: 10.1021/cn900017w. PMC2843917.


29. Makos MA, Kuklinski NJ, Berglund EC, Heien ML, Ewing AG. Chemical Measurements in Drosophila. Trends in Analytical Chemistry. 2009 28(11), 1223-1234.

28. Keithley RM, Heien ML, Wightman RM. Multivariate concentration determination using principal component regression with residual analysis. Trends in Analytical Chemistry. 2009, 28(9), 1127 – 1136. doi: 10.1016/j.trac.2009.07.002

27. Santillo MF, Heien ML, Ewing AG. Temporal analysis of protozoan lysis in a microfluidic device. Lab on a Chip. 2009 9, 2796 – 2802. doi: 10.1039/B907942D

26. Piehowski PD, Davey AM, Kurczy ME, Sheets ED, Winograd N, Ewing AG, Heien ML. ToF-SIMS imaging of sub-cellular lipid heterogeneity: Poisson counting and spatial resolution. Analytical Chemistry. 2009 81(14), 5593-5602. doi: 10.1021/ac901065s

25. Omiatek DM, Santillo MF, Heien ML, Ewing AG. Hybrid capillary-microfluidic device for the separation, lysis, and electrochemical detection of vesicles. Analytical Chemistry. 2009 81(6), 2294 – 2302. doi: 10.1021/ac802466g

24. Makos MA, Kim YC, Han KA, Heien ML, Ewing AG. In Vivo Electrochemical measurements of exogenously applied dopamine in Drosophila melanogaster. Analytical Chemistry. 2009 81(5), 1848 – 1854. doi: 10.1021/ac802297b

23. Hanson JN, Motala MJ, Heien ML, Gillette M, Sweedler J, Nuzzo RG. Textural guidance cues for controlling process outgrowth of mammalian neurons. Lab on a Chip. 2009 9(1), 122 – 131. doi: 10.1039/b803595d

22. Heien ML, Ewing AG. Quantitative chemical analysis of single cells. Microfluidics and Nanotechnology, Humana Press Methods in Molecular Biology series. 2009 544, 153 – 162.


21. Dong Y, Heien ML, Maxon MM, Ewing AG. Amperometric measurements of catecholamine release from single vesicles in MN9D cells. Journal of Neurochemistry. 2008 107(6), 1589 – 1595. doi: 10.1111/j.1471-4159.2008.05721.x

20. Piehowski PD, Carado A, Kurczy ME, Ostrowski S, Heien ML, Winograd N, Ewing AG. MS/MS methodology to improve sub-cellular mapping of cholesterol using ToF-SIMS. Analytical Chemistry. 2008 80(22), 8662 – 8667. doi: 10.1021/ac801591r

19. Piehowski PD, Kurczy ME, Willingham D, Parry S, Heien ML, Winograd N, Ewing AG. Freeze-etching and vapor matrix deposition for ToF-SIMS imaging of single cells. Langmuir. 2008 24(15), 7906 – 7911. doi: 10.1021/la800292e

18. Zhang B, Adams KL, Luber SJ, Eves DJ, Heien ML, Ewing AG. Spatially and temporally resolved single-cell exocytosis utilizing individually addressable carbon microelectrode arrays. Analytical Chemistry. 2008 80(5), 1394 – 1400. doi: 10.1021/ac702409s


17. Jo K, Heien ML, Thompson LB, Zhong M, Nuzzo RG, Sweedler JV. Mass spectrometric imaging of peptide release from neuronal cells within microfluidic devices. Lab on a Chip. 2007 7(11), 1454 – 1460. doi: 10.1039/b706940e

16. Wightman RM, Heien ML, Wassum KM, Sombers LA, Aragona BJ, Khan AS, Ariansen JL, Cheer JF, Phillips PE, Carelli RM. Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens. European Journal of Neuroscience. 2007 26(7), 2046 – 2054. doi: 10.1111/j.1460-9568.2007.05772.x

15. Cheer JF, Aragona BJ, Heien ML, Seipel AT, Carelli RM, Wightman RM. Coordinated accumbal dopamine release and neural activity drive goal-directed behavior. Neuron. 2007 54(2), 237 – 244. doi: 10.1016/j.neuron.2007.03.021

14. Cheer JF, Wassum KM, Sombers LA, Heien ML, Ariansen JL, Aragona BJ, Phillips PE, Wightman RM. Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation. Journal of Neuroscience. 2007 27(4), 791 – 795. doi: 10.1523/JNEUROSCI.4152-06.2007

13. Rubakhin SS, Hatcher NG, Monroe EB, Heien ML, Sweedler JV. Mass spectrometric imaging of the nervous system. Current Pharmaceutical Design. 2007 13(32), 3325 – 3334.


12. Heien ML, Wightman RM. Phasic dopamine signaling during behavior, reward, and disease states. CNS Neurological Disorders – Current Drug Targets. 2006 5(1) 99 – 108.


11. Cheer JF, Heien ML, Garris PA, Carelli RM, Wightman RM. Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: implications for intracranial self-stimulation. Proceedings of the National Academy of Sciences USA. 2005 102(52) 19150 – 19155. doi: 10.1073/pnas.0509607102

10. Heien, ML, Khan AS, Ariansen JL, Cheer JF, Phillips PEM, Wassum KM, Wightman RM. Real-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats. Proceedings of the National Academy of Sciences USA. 2005 102(29) 10023 – 10028. doi: 10.1073/pnas.0504657102


9. Heien ML, Johnson MA, Wightman RM. Resolving neurotransmitters detected by fast-scan cyclic voltammetry. Analytical Chemistry. 2004 76(19) 5697 – 5704. doi: 10.1021/ac0491509

8. Forry SP, Murray JR, Heien ML, Locascio LE, Wightman RM. Probing electric fields inside microfluidic channels during electroosmotic flow with fast-scan cyclic voltammetry. Analytical Chemistry. 2004 76(17) 4945 – 4950. doi: 10.1021/ac049591s

7. Song Y, Heien ML, Jimenez V, Wightman RM, Murray RW. Voltammetric detection of metal nanoparticles separated by liquid chromatography. Analytical Chemistry. 2004 76(17), 4911 – 4919. doi: 10.1021/ac049223o

6. Cheer JF, Wassum KM, Heien ML, Phillips PEM, Wightman RM. Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats. Journal of Neuroscience. 2004 24(18), 4393 – 4400. doi: 10.1523/jneurosci.0529-04.2004


5. Heien ML, Phillips PEMP, Stuber GD, Seipel AT, Wightman RM. Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity. Analyst. 2003 128(12), 1413 – 1419. doi: 10.1039/b307024g

4. Robinson DL, Venton BJ, Heien ML, Wightman RM. Detecting subsecond dopamine release with fast-scan cyclic voltammetry in vivo. Clinical Chemistry. 2003 49(10), 1763 – 1773. doi: 10.1373/49.10.1763

3. Phillips PEMP, Stuber GD, Heien ML, Wightman RM, Carelli RM. Subsecond dopamine release promotes cocaine seeking. Nature. 2003 422(6932), 614 – 618. doi: 10.1038/nature01476


2. Robinson DL, Heien ML, Wightman RM. Frequency of dopamine concentration transients increases in dorsal and ventral striatum of male rats during introduction of conspecifics. Journal of Neuroscience. 2002 22(23), 10477 – 10486.

1. Troyer KP, Heien ML, Venton BJ, Wightman RM. Neurochemistry and electroanalytical probes. Current Opinions in Chemical Biology. 2002 6(5), 696 – 703. doi: 10.1016/s1367-5931(02)00374-5

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