Publications

2016

  1. Meier, A. R.; Bahureksa, W. A.; Heien, M. L. Elucidating the Structure–Function Relationship of Poly(3,4-theylenedioxythiophene) Films to Advance Electrochemical Measurements. J. Phys. Chem. C 2016, 120 (37), 21114–21122 DOI: 10.1021/acs.jpcc.6b04622.
  2. Meier, A. R.; Matteucci, M.; Vreeland, R. F.; Taboryski, R.; Heien, M. L. Rapid Voltammetric Measurements at Conducting Polymer Microelectrodes Using Ultralow-Capacitance Poly(3,4-ethylenedioxythiophene):Tosylate. Langmuir 2016, 32 (32), 8009–8018 DOI: 10.1021/acs.langmuir.6b01423 PMID:27483032.
  3. Bartlett, M. J.; Joseph, R. M.; LePoidevin, L. M.; Parent, K. L.; Laude, N. D.; Lazarus, L. B.; Heien, M. L.; Estevez, M.; Sherman, S. J.; Falk, T. Long-term effect of sub-anesthetic ketamine in reducing l-DOPA-induced dyskinesias in a preclinical model. Neurosci. Lett. 2016, 612, 121–125 DOI: 10.1016/j.neulet.2015.11.047 PMID:26644333.

2015

  1. Atcherley, C. W.; Laude, N. D.; Monroe, E. B.; Wood, K. M.; Hashemi, P.; Heien, M. L. Improved Calibration of Voltammetric Sensors for Studying Pharmacological Effects on Dopamine Transporter Kinetics in Vivo. ACS Chem. Neurosci. 2014, 6 (9), 1509–1516 DOI: 10.1021/cn500020s PMID:25062330.
  2. Vreeland, R. F.; Atcherley, C. W.; Russell, W. S.; Xie, J. Y.; Lu, D.; Laude, N. D.; Porreca, F.; Heien, M. L. Biocompatible PEDOT:Nafion composite electrode coatings for selective detection of neurotransmitters in vivo. Anal. Chem. 2015, 87 (5), 2600–2607 DOI: 10.1021/ac502165f PMID:25692657.
  3. Atcherley, C. W.; Wood, K. M.; Parent, K. L.; Hashemi, P.; Heien, M. L. The coaction of tonic and phasic dopamine dynamics. Chem. Commun. (Camb). 2015, 51 (12), 2235–2238 DOI: 10.1039/c4cc06165a PMID:25249291.

2014

  1. Pathirathna, P.; Samaranayake, S.; Atcherley, C. W.; Parent, K. L.; Heien, M. L.; McElmurry, S. P.; Hashemi, P. Fast voltammetry of metals at carbon-fiber microelectrodes: copper adsorption onto activated carbon aids rapid electrochemical analysis. Analyst 2014, 139 (18), 4673–4680 DOI: 10.1039/c4an00937a PMID:25051455.
  2. Dong, Y.; Ning, G.; Ewing, A. G.; Heien, M. L. Pituitary Adenylate Cyclase Activating Polypeptide Modulates Catecholamine Storage and Exocytosis in PC12 Cells. PLoS One 2014, 9 (3), e91132 DOI: 10.1371/journal.pone.0091132 PMID:24603879.
  3. Flores, A. J.; Bartlett, M. J.; So, L. Y.; Laude, N. D.; Parent, K. L.; Heien, M. L.; Sherman, S. J.; Falk, T. Differential effects of the NMDA receptor antagonist MK-801 on dopamine receptor D1- and D2-induced abnormal involuntary movements in a preclinical model. Neurosci. Lett. 2014, 564, 48–52 DOI: 10.1016/j.neulet.2014.02.004 PMID:24525249.
  4. Vreeland, R. F.; Laude, N. D.; Lambert, S. M.; Heien, M. L. Microwave-plasma dry-etch for fabrication of conducting polymer microelectrodes. Anal. Chem. 2014, 86 (3), 1385–1390 DOI: 10.1021/ac403363a PMID:24417474.

2013

  1. Atcherley, C. W.; Laude, N. D.; Parent, K. L.; Heien, M. L. Fast-scan controlled-adsorption voltammetry for the quantification of absolute concentrations and adsorption dynamics. Langmuir 2013, 29 (48), 14885–14892 DOI: 10.1021/la402686s PMID:24245864.
  2. Atcherley, C. W.; Vreeland, R. F.; Monroe, E. B.; Sanchez-Gomez, E.; Heien, M. L. Rethinking data collection and signal processing. 2. Preserving the temporal fidelity of electrochemical measurements. Anal. Chem. 2013, 85 (16), 7654–7658 DOI: 10.1021/ac402037k PMID:23919317.
  3. Monroe, E. B.; Heien, M. L. Electrochemical generation of hydroxyl radicals for examining protein structure Electrochemical generation of hydroxyl radicals for examining protein structure. 2013 DOI: 10.1021/ac400107c.
  4. Berglund, E. C.; Makos, M. A.; Keighron, J. D.; Phan, N.; Heien, M. L.; Ewing, A. G. Oral administration of methylphenidate blocks the effect of cocaine on uptake at the Drosophila dopamine transporter. ACS Chem. Neurosci. 2013, 4 (4), 566–574 DOI: 10.1021/cn3002009 PMID:23402315.
  5. Omiatek, D. M.; Bressler, A. J.; Cans, A.-S.; Andrews, A. M.; Heien, M. L.; Ewing, A. G. The real catecholamine content of secretory vesicles in the CNS revealed by electrochemical cytometry. Sci. Rep. 2013, 3, 1447 DOI: 10.1038/srep01447 PMID:23486177.

2012

  1. Laude, N. D.; Atcherley, C. W.; Heien, M. L. Rethinking data collection and signal processing. 1. Real-time oversampling filter for chemical measurements. Anal. Chem. 2012, 84 (19), 8422–8426 DOI: 10.1021/ac302169y PMID:22978644.
  2. Larsen, S. T.; Heien, M. L.; Taboryski, R. Amperometric noise at thin film band electrodes. Anal. Chem. 2012, 84 (18), 7744–7749 DOI: 10.1021/ac301136x PMID:22928986.
  3. Ariansen, J. L.; Heien, M. L. A. V; Hermans, A.; Phillips, P. E. M.; Hernadi, I.; Bermudez, M. A.; Schultz, W.; Wightman, R. M. Monitoring extracellular pH, oxygen, and dopamine during reward delivery in the striatum of primates. Front. Behav. Neurosci. 2012, 6 (July), 36 DOI: 10.3389/fnbeh.2012.00036 PMID:22783176.
  4. Larsen, S. T.; Vreeland, R. F.; Heien, M. L.; Taboryski, R. Characterization of poly(3,4-ethylenedioxythiophene):tosylate conductive polymer microelectrodes for transmitter detection. Analyst 2012, 137 (8), 1831–1836 DOI: 10.1039/c2an16288a PMID:22383043.

2011

  1. Zhang, B.; Heien, M. L. A. V; Santillo, M. F.; Mellander, L.; Ewing, A. G. Temporal resolution in electrochemical imaging on single PC12 cells using amperometry and voltammetry at microelectrode arrays. Anal. Chem. 2011, 83 (2), 571–577 DOI: 10.1021/ac102502g PMID:21190375.
  2. Santillo, M. F.; Ewing, A. G.; Heien, M. L. Trends in computational simulations of electrochemical processes under hydrodynamic flow in microchannels. Anal. Bioanal. Chem. 2011, 399 (1), 183–190 DOI: 10.1007/s00216-010-4070-4 PMID:20734034.

2010

  1. Dominak, L. M.; Omiatek, D. M.; Gundermann, E. L.; Heien, M. L.; Keating, C. D. Polymeric crowding agents improve passive biomacromolecule encapsulation in lipid vesicles. Langmuir 2010, 26 (16), 13195–13200 DOI: 10.1021/la101903r PMID:20695558.
  2. Omiatek, D. M.; Cans, A.-S.; Heien, M. L.; Ewing, A. G. Analytical approaches to investigate transmitter content and release from single secretory vesicles. Anal. Bioanal. Chem. 2010, 397 (8), 3269–3279 DOI: 10.1007/s00216-010-3698-4 PMID:20480152.
  3. Heien, M. L.; Piehowski, P. D.; Winograd, N.; Ewing, A. G. Lipid detection, identification, and imaging single cells with SIMS. Methods Mol. Biol. 2010, 656, 85–97 DOI: 10.1007/978-1-60761-746-4_4 PMID:20680585.
  4. Makos, M. A.; Omiatek, D. M.; Ewing, A. G.; Heien, M. L. Development and characterization of a voltammetric carbon-fiber microelectrode pH sensor. Langmuir 2010, 26 (12), 10386–10391 DOI: 10.1021/la100134r PMID:20380393.
  5. Kurczy, M. E.; Piehowsky, P. D.; Willingham, D.; Molyneaux, K. A.; Heien, M. L.; Winograd, N.; Ewing, A. G. Nanotome cluster bombardment to recover spatial chemistry after preparation of biological samples for SIMS imaging. J. Am. Soc. Mass Spectrom. 2010, 21 (5), 833–836 DOI: 10.1016/j.jasms.2010.01.014 PMID:20219392.
  6. Dong, Y.; Heien, M. L.; Kurczy, M. E.; Ewing, A. G. Probing Exocytosis at Single Cells Using Electrochemistry. In Chemical Cytometry; Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany, 2010; pp 159–174.
  7. Omiatek, D. M.; Dong, Y.; Heien, M. L.; Ewing, A. G. Only a Fraction of Quantal Content is Released During Exocytosis as Revealed by Electrochemical Cytometry of Secretory Vesicles. ACS Chem. Neurosci. 2010, 1 (3), 234–245 DOI: 10.1021/cn900040e PMID:20368748.
  8. Kurczy, M. E.; Piehowski, P. D.; Van Bell, C. T.; Heien, M. L.; Winograd, N.; Ewing, A. G. Mass spectrometry imaging of mating Tetrahymena show that changes in cell morphology regulate lipid domain formation. Proc. Natl. Acad. Sci. 2010, 107 (7), 2751–2756 DOI: 10.1073/pnas.0908101107 PMID:20133641.
  9. Adams, K. L.; Engelbrektsson, J.; Voinova, M.; Zhang, B.; Eves, D. J.; Karlsson, R.; Heien, M. L.; Cans, A.-S.; Ewing, A. G. Steady-State Electrochemical Determination of Lipidic Nanotube Diameter Utilizing an Artificial Cell Model. Anal. Chem. 2010, 82 (3), 1020–1026 DOI: 10.1021/ac902282d PMID:20039639.
  10. Makos, M. a; Han, K.-A.; Heien, M. L.; Ewing, A. G. Using In Vivo Electrochemistry to Study the Physiological Effects of Cocaine and Other Stimulants on the Drosophila melanogaster Dopamine Transporter. ACS Chem. Neurosci. 2010, 1 (1), 74–83 DOI: 10.1021/cn900017w PMID:20352129.

2009

  1. Makos, M. A.; Kuklinski, N. J.; Berglund, E. C.; Heien, M. L.; Ewing, A. G. Chemical measurements in Drosophila. Trends Analyt. Chem. 2009, 28 (11), 1223–1234 DOI: 10.1016/j.trac.2009.08.005 PMID:20161412.
  2. Keithley, R. B.; Heien, M. L.; Wightman, R. M. Multivariate concentration determination using principal component regression with residual analysis. Trends Analyt. Chem. 2009, 28 (9), 1127–1136 DOI: 10.1016/j.trac.2009.07.002 PMID:20160977.
  3. Santillo, M. F.; Heien, M. L.; Ewing, A. G. Temporal analysis of protozoan lysis in a microfluidic device. Lab Chip 2009, 9 (19), 2796–2802 DOI: 10.1039/b907942d PMID:19967116.
  4. Piehowski, P. D.; Davey, A. M.; Kurczy, M. E.; Sheets, E. D.; Winograd, N.; Ewing, A. G.; Heien, M. L. Time-of-flight secondary ion mass spectrometry imaging of subcellular lipid heterogeneity: Poisson counting and spatial resolution. Anal. Chem. 2009, 81 (14), 5593–5602 DOI: 10.1021/ac901065s PMID:19530687.
  5. Omiatek, D. M.; Santillo, M. F.; Heien, M. L.; Ewing, A. G. Hybrid Capillary-Microfluidic Device for the Separation, Lysis, and Electrochemical Detection of Vesicles. Anal. Chem. 2009, 81 (6), 2294–2302 DOI: 10.1021/ac802466g PMID:19228035.
  6. Makos, M. A.; Kim, Y.-C.; Han, K.-A.; Heien, M. L.; Ewing, A. G. In Vivo Electrochemical Measurements of Exogenously Applied Dopamine in Drosophila melanogaster. Anal. Chem. 2009, 81 (5), 1848–1854 DOI: 10.1021/ac802297b PMID:19192966.
  7. Hanson, J. N.; Motala, M. J.; Heien, M. L.; Gillette, M.; Sweedler, J.; Nuzzo, R. G. Textural guidance cues for controlling process outgrowth of mammalian neurons. Lab Chip 2009, 9 (1), 122–131 DOI: 10.1039/B803595D PMID:19209344.
  8. Heien, M. L.; Ewing, A. G. Quantitative chemical analysis of single cells. Methods Mol. Biol. 2009, 544, 153–162 DOI: 10.1007/978-1-59745-483-4_11 PMID:19488699.

2008

  1. Dong, Y.; Heien, M. L.; Maxson, M. M.; Ewing, A. G. Amperometric measurements of catecholamine release from single vesicles in MN9D cells. J. Neurochem. 2008, 107 (6), 1589–1595 DOI: 10.1111/j.1471-4159.2008.05721.x PMID:19094057.
  2. Piehowski, P. D.; Carado, A. J.; Kurczy, M. E.; Ostrowski, S. G.; Heien, M. L.; Winograd, N.; Ewing, A. G. MS/MS Methodology To Improve Subcellular Mapping of Cholesterol Using TOF-SIMS. Anal. Chem. 2008, 80 (22), 8662–8667 DOI: 10.1021/ac801591r PMID:18925746.
  3. Piehowski, P. D.; Kurczy, M. E.; Willingham, D.; Parry, S.; Heien, M. L.; Winograd, N.; Ewing, A. G. Freeze-etching and vapor matrix deposition for ToF-SIMS imaging of single cells. Langmuir 2008, 24 (15), 7906–7911 DOI: 10.1021/la800292e PMID:18570446.
  4. Zhang, B.; Adams, K. L.; Luber, S. J.; Eves, D. J.; Heien, M. L.; Ewing, A. G. Spatially and temporally resolved single-cell exocytosis utilizing individually addressable carbon microelectrode arrays. Anal. Chem. 2008, 80 (5), 1394–1400 DOI: 10.1021/ac702409s PMID:18232712.

2007

  1. Jo, K.; Heien, M. L.; Thompson, L. B.; Zhong, M.; Nuzzo, R. G.; Sweedler, J. V. Mass spectrometric imaging of peptide release from neuronal cells within microfluidic devices. Lab Chip 2007, 7 (11), 1454–1460 DOI: 10.1039/b706940e PMID:17960271.
  2. Wightman, R. M.; Heien, M. L. A. V; Wassum, K. M.; Sombers, L. A.; Aragona, B. J.; Khan, A. S.; Ariansen, J. L.; Cheer, J. F.; Phillips, P. E. M.; Carelli, R. M. Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens. Eur. J. Neurosci. 2007, 26 (7), 2046–2054 DOI: 10.1111/j.1460-9568.2007.05772.x PMID:17868375.
  3. Cheer, J. F.; Aragona, B. J.; Heien, M. L. A. V; Seipel, A. T.; Carelli, R. M.; Wightman, R. M. Coordinated accumbal dopamine release and neural activity drive goal-directed behavior. Neuron 2007, 54 (2), 237–244 DOI: 10.1016/j.neuron.2007.03.021 PMID:17442245.
  4. Cheer, J. F.; Wassum, K. M.; Sombers, L. A.; Heien, M. L. A. V; Ariansen, J. L.; Aragona, B. J.; Phillips, P. E. M.; Wightman, R. M. Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation. J. Neurosci. 2007, 27 (4), 791–795 DOI: 10.1523/JNEUROSCI.4152-06.2007 PMID:17251418.
  5. Rubakhin, S.; Hatcher, N.; Monroe, E.; Heien, M.; Sweedler, J. Mass Spectrometric Imaging of the Nervous System. Curr. Pharm. Des. 2007, 13 (32), 3325–3334 DOI: 10.2174/138161207782360708 PMID:18045186.

2006

  1. Heien, M. L. A. V; Wightman, R. M. Phasic dopamine signaling during behavior, reward, and disease states. CNS Neurol. Disord. Drug Targets 2006, 5 (1), 99–108 DOI: 10.2174/187152706784111605 PMID:16613556.

2005

  1. Cheer, J. F.; Heien, M. L. A. V.; Garris, P. A.; Carelli, R. M.; Wightman, R. M. Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: implications for intracranial self-stimulation. Proc. Natl. Acad. Sci. U. S. A. 2005, 102 (52), 19150–19155 DOI: 10.1073/pnas.0509607102 PMID:16380429.
  2. Heien, M. L. A. V; Khan, A. S.; Ariansen, J. L.; Cheer, J. F.; Phillips, P. E. M.; Wassum, K. M.; Wightman, R. M. Real-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats. Proc. Natl. Acad. Sci. U. S. A. 2005, 102 (29), 10023–10028 DOI: 10.1073/pnas.0504657102 PMID:16006505.

2004

  1. Heien, M. L. A. V; Johnson, M. A.; Wightman, R. M. Resolving neurotransmitters detected by fast-scan cyclic voltammetry. Anal. Chem. 2004, 76 (19), 5697–5704 DOI: 10.1021/ac0491509 PMID:15456288.
  2. Forry, S. P.; Murray, J. R.; Heien, M. L. A. V; Locascio, L. E.; Wightman, R. M. Probing electric fields inside microfluidic channels during electroosmotic flow with fast-scan cyclic voltammetry. Anal. Chem. 2004, 76 (17), 4945–4950 DOI: 10.1021/ac049591s PMID:15373427.
  3. Song, Y.; Heien, M. L.; Jimenez, V.; Wightman, R. M.; Murray, R. W. Voltammetric detection of metal nanoparticles separated by liquid chromatography. Anal. Chem. 2004, 76 (17), 4911–4919 DOI: 10.1021/ac049223o PMID:15373423.
  4. Cheer, J. F.; Wassum, K. M.; Heien, M. L. A. V; Phillips, P. E. M.; Wightman, R. M. Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats. J. Neurosci. 2004, 24 (18), 4393–4400 DOI: 10.1523/JNEUROSCI.0529-04.2004 PMID:15128853.

2003

  1. Heien, M. L. a V; Phillips, P. E. M.; Stuber, G. D.; Seipel, A. T.; Wightman, R. M. Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity. Analyst 2003, 128 (12), 1413–1419 DOI: 10.1039/b307024g PMID:14737224.
  2. Robinson, D. L.; Venton, B. J.; Heien, M. L. A. V; Wightman, R. M. Detecting subsecond dopamine release with fast-scan cyclic voltammetry in vivo. Clin. Chem. 2003, 49 (10), 1763–1773 DOI: 10.1373/49.10.1763 PMID:14500617.
  3. Phillips, P. E. M.; Stuber, G. D.; Heien, M. L. A. V; Wightman, R. M.; Carelli, R. M. Subsecond dopamine release promotes cocaine seeking. Nature 2003, 422 (6932), 614–618 DOI: 10.1038/nature01476 PMID:12687000.

2002

  1. Robinson, D. L.; Heien, M. L. a V; Wightman, R. M. Frequency of dopamine concentration transients increases in dorsal and ventral striatum of male rats during introduction of conspecifics. J. Neurosci. 2002, 22 (23), 10477–10486 DOI: 22/23/10477 [pii] PMID:12451147.
  2. Troyer, K. P.; Heien, M. L. A. V; Venton, B. J.; Wightman, R. M. Neurochemistry and electroanalytical probes. Curr. Opin. Chem. Biol. 2002, 6 (5), 696–703 DOI: 10.1016/S1367-5931(02)00374-5 PMID:12413556.

Other Publications

  • Heien ML, Sweedler JV. Solution to the neurochemical challenge.  Analytical and Bioanalytical Chemistry.  2007, 388(1): 3. doi: 10.1007/s00216-007-1200-8.  PMID: 17340082.
  • Heien ML, Sweedler JV. Neurochemical challenge.  Analytical and Bioanalytical Chemistry.  2007, 387(1): 3-4. doi: 10.1007/s00216-006-0932-1.  PMID: 17111104.
  • Heien ML, Wightman RM. Carbon-Fiber Microelectrodes: Fabrication and treatments. Axobits. 2004, 41: 5-6.

Patents

  • Vreeland RF, Heien ML, 2014. “Sulfonated tetrafluoroethylene based ionomer coated carbon fiber”. Provisional U.S. Patent application no. 62/085,438 filed November 28, 2014.